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Sodium bicarbonate and sodium carbonate are generally recognized as safe by food safety authorities worldwide, including the U.S. Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA). However, as with any food additive, it is essential to consume them in moderation. Overconsumption of products containing high levels of sodium can lead to health issues, such as hypertension or other cardiovascular problems.

In agricultural practices, manganese deficiency can pose significant challenges. Certain soil types, particularly acidic and sandy soils, are prone to manganese deficiency. Additionally, high levels of calcium and magnesium can inhibit manganese absorption, further exacerbating the problem. Symptoms of manganese deficiency in plants include interveinal chlorosis, where the spaces between leaf veins turn yellow while the veins remain green. This not only reduces the aesthetic value of crops but also compromises yield and quality. To combat these issues, the application of manganese fertilizers has become an essential practice.